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There are four complementary projects that comprise the Neuromuscular
Disease Project. These are:
Project 1: The
Kunkel Laboratory
Gene expression and biochemical studies of filamin/sarcoglycan-related
dystrophies.
Project 2: The
Brown Laboratory (Day Neuromuscular Research Laboratory)
Gene expression and biochemical studies of dysferlin-related
dystrophies.
Project 3: The
Beggs Laboratory
Gene Expression and Biochemical Analysis of Muscle Development
in Myotubular Myopathy.
Project 4: The
Gussoni Laboratory
Gene expression in, and therapeutic application of,
muscle stem cells.
The common fundamental goals of the projects is characterizing
and understanding normal and abnormal patterns of gene expression
in developing muscle from the stem cell state through to maturity.
Further, we aim to understand the molecular consequences of
specific genetic defects and to identify appropriate targets
for therapeutic intervention.
Based on these fundamental goals, there are three complementary
approaches to our research:
- To enroll patients with specific neuromuscular disorders
in our research
- To identify new muscle-specific genes and proteins through
biochemical and molecular analysis
- To research gene expression using microarray technology
Patients who are interested in learning more about our research
can visit Our Research
link. Health care professionals and researchers interested
in learning more can visit the Researcher
section of this web site.
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